In collaboration with several other groups from the Barcelona area we have  published the  article ‘Rett-like severe encephalopathy caused by a de novo GRIN2B mutation is attenuated by D-serine dietary supplement‘  in the prestigious journal Biological Psychiatry. In this article we show that hypofunctional NMDARs can contribute to Rett-like encephalopathy, and that their potentiation by D-serine treatment may underlie the associated clinical improvement.