The Spanish Ministry for Economy and Competitivity will keep funding our research network ‘Synaptic Role in Cognitive Disabilities Network‘ (http://www.syncogdis.org/).
In this network we have brought together scientists from many different disciplines with the goal to accelerate research in the study of the synaptic role in brain disorders such as neurodevelopmental conditions and neurodegenerative diseases.
An European scientific consortium lead by our research group has been granted with an ERA-NET NEURON grant to support the research project “Synaptic Dysfunction in Intellectual Disability Caused by SYNGAP1. Translational Research to Develop Human Models and Advance Pharmacological Treatments”. The main goal of this project is to make iPSCs harbouring SYNGAP1 mutations causing intellectual disability and to use them to identify new potential treatments.
This project will start in the first semester of 2018 and finish in 2021.
We have published a meta-analysis paper where we critically review the proteomics data acquired over the year to elucidate synaptic mechanism of Mental Disease. We suggest that future research in the field will require higher levels of standardization and larger-scale experiments to address the challenge posed by biological and methodological variability.
Rita Reig-Viader, Carlos Sindreu and Àlex Bayés.
Synaptic proteomics as a means to identify the molecular basis of mental illness: are we getting there?
Progress in Neuropsychopharmacology and Biological Psychiatry. 2017 Sep 20. pii: S0278-5846(17)30461-X.
The second meeting of the SynCogDis research network, coordinated by our group, will take place in Alicante the 28th and 29th of July in the context of the SENC (Sociedad Española de Neurociencias) meeting.
We have published a methods paper describing the biochemical tools that we have developed over the years and use routinely in the lab to isolate synapses and sub-synaptic protein complexes for proteomic characterisation:
Rita Reig-Viader and Àlex Bayés. Quantitative In-Depth profiling of the Postsynaptic Density Proteome to Understand the Molecular Mechanisms Governing Synaptic Physiology and Pathology. Current Proteomic Approaches Applied to Brain Function. 2017 Human Press, Springer Protocols. ISBN 978-1-4939-7119-0.
In collaboration with several other groups from the Barcelona area we have published the article ‘Rett-like severe encephalopathy caused by a de novo GRIN2B mutation is attenuated by D-serine dietary supplement‘ in the prestigious journal Biological Psychiatry. In this article we show that hypofunctional NMDARs can contribute to Rett-like encephalopathy, and that their potentiation by D-serine treatment may underlie the associated clinical improvement.
Our paper entitled ‘Evolution of complexity in the zebrafish synapse proteome’ has just been released in the web of Nature Communications. Read.
Just released the review about neurological conditions caused by genes expressed at the pre-synaptic boutton.
We have recently published the article ‘Synapse Proteomes and Disease: The MASC Paradigm‘ as part of the book ‘Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability’ (Academic Press, 2016).
The first meeting of the SynCogDis research network, coordinated by our group, will take place in Copenhagen the 3rd and 4th of July in the context of the FENS (Federation of European Neuroscience Society) meeting.